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A nurse born in Bracebridge Ontario in 1888, Marie Caisse, is credited with formulating this herbal blend after learning of the healing properties of the different herbs from a patient who was cured of cancer by an Ojibwe neighbour. She used it to treat cancer in her patients in Northern Ontario and while physicians took note and several petitions were made to Health Canada from 1926 to 1938 to allow it's use on a larger scale, all were rejected. She left the recipe to a Canadian corporation for $1.00 just before her death in 1977 but to date, no large scale trials have been conducted to measure the efficacy of this herbal blend. There is a lot of anectodate evidence out there for you to research.